Professor Mattheos Koffas, Ph.D., received his B.S. degree in Chemical Engineering from the National Technical University in Athens, Greece in 1994. He then joined the graduate program of the Department of Chemical Engineering at MIT where he worked on improving amino acid biosynthesis from Corynebacterium glutamicum. After completing his Ph.D. in 2000, he joined DuPont’s Central Research and Development as a research scientist where he worked on engineering the carotenoid biosynthesis of an obligate methanotroph. In August of 2002 he joined the faculty of the Department of Chemical and Biological Engineering at SUNY Buffalo as a tenure-track Assistant Professor and was promoted to Associate Professor with tenure in the summer of 2008. In January of 2011 Prof. Koffas moved to his current position at Rensselaer. He was appointed Dorothy and Fred Chau '71 Career Development Constellation Professor in Biocatalysis and Metabolic Engineering in 2015. In his research career, Dr. Koffas has worked with a variety of microorganisms and natural products including amino acids, polyphenols, fatty acids and terpenoids. He has published more than 65 peer-reviewed publications, more than 12 book chapters and holds 10 patents. He is a member of the editorials boards of various journals in the area of bioengineering. His research has been funded by federal agencies (NIH and NSF), the state of New York (NYStem), and industrial partners (Evonik, Firstwave Technologies and Chromadex).
B.S. National Technical University, Athens, Greece, 1994 Ph.D. Massachusetts Institute of Technology, 2000
Focus AreaMetabolic Engineering, Industrial Microbiology, Synthetic Biology, Natural Products
Selected Scholarly WorksImproving fatty acids production by engineering dynamic pathway regulation and metabolic control. Xu P, Li L, Zhang F, Stephanopoulos G, Koffas M. Proc Natl Acad Sci U S A. 2014 Aug 5;111(31):11299-304. doi: 10.1073/pnas.1406401111. Epub 2014 Jul 21.
Masquerading microbial pathogens: capsular polysaccharides mimic host-tissue molecules. Cress BF, Englaender JA, He W, Kasper D, Linhardt RJ, Koffas MA. FEMS Microbiol Rev. 2014 Jul;38(4):660-97. doi: 10.1111/1574-6976.12056. Epub 2014 Jan 27.
Design and kinetic analysis of a hybrid promoter-regulator system for malonyl-CoA sensing in Escherichia coli. Xu P, Wang W, Li L, Bhan N, Zhang F, Koffas MA. ACS Chem Biol. 2014 Feb 21;9(2):451-8. doi: 10.1021/cb400623m. Epub 2013 Nov 19.
ePathBrick: a synthetic biology platform for engineering metabolic pathways in E. coli. Xu P, Vansiri A, Bhan N, Koffas MA. ACS Synth Biol. 2012 Jul 20;1(7):256-66. doi: 10.1021/sb300016b. Epub 2012 May 4.
Modular optimization of multi-gene pathways for fatty acids production in E. coli. Xu P, Gu Q, Wang W, Wong L, Bower AG, Collins CH, Koffas MA. Nat Commun. 2013;4:1409. doi: 10.1038/ncomms2425.
Improving fatty acids production by engineering dynamic pathway regulation and metabolic control. Xu P, Li L, Zhang F, Stephanopoulos G, Koffas M. Proc Natl Acad Sci U S A. 2014 Aug 5;111(31):11299-304