Todd Przybycien

Todd Przybycien
Contact Information
Office: CBIS 4105
Phone: 518-276-2793
Ph.D. Chemical Engineering, California Institute of Technology,1989
M.S. Chemical Engineering, California Institute of Technology, 1987
B.S. Chemical Engineering, Washington University, 1984
A.B. Chemistry, Washington University, 1984
Professor Todd Przybycien received a BS in Chemical Engineering and a AB in Chemistry from Washington University in St. Louis in 1984. He attended California Institute of Technology for graduate education, receiving MS and PhD degrees in Chemical Engineering in 1987 and 1989. Prof. Przybycien worked for two years at Monsanto Agricultural Company as a Senior Research Engineer before joining Rensselaer Polytechnic Institute as an Assistant Professor in 1991. He came to Chemical Engineering at Carnegie Mellon in 1996 and served as the (founding) Head of BioMedical Engineering from 2002-2008. Professor Przybycien currently holds a joint appointment in Biomedical Engineering and in Chemical Engineering.
Research Interests
Downstream Bioprocessing, Drug Delivery, Medical Device Development
Current Research
Professor Przybycien's group works on industrial downstream bioprocessing and on drug delivery and medical device development. These activities are linked via fundamental interests in biophysics and in colloid and interface science. Their approach is to use spectroscopic, optical, physical, simulation and informatics tools to connect microscopic, molecular-level behavior to macroscopic, process-level engineering decision variables. Current research topics include: Downstream Processing Topics Development of next-generation macromolecular affinity chromatography media based on PEGylated ligands. Chromatographic performance as a function of systematic and stochastic uncertainty in mobile phase delivery. Continuous precipitation-based processes for protein purification. Single-use versus multi-use process equipment decision-making. Protein/Drug Delivery Topics Overcoming interfacial denaturation in the delivery of proteins from poly(lactide-co-glycolide) microspheres via protein PEGylation (in collaboration with Professor Tilton). Enhancing spreading, mucolysis and antimicrobial activity in pulmonary drug delivery with surfactants (in collaboration with Professors Garoff and Tilton). Protein Adsorption Topics Impact of micro-scale and nano-scale surface features on protein adsorption behavior. Anti-microbial adsorbed protein layers (in collaboration with Prof. Tilton). Device Development Topics Development of a hand-held tissue reflectance spectrometer for detection of incipient pressure ulcers regardless of skin pigmentation