Steven M. Cramer

Steven M. Cramer
William Weightman Walker Professor
Contact Information
Office: CBIS 3211
Phone: 518-276-6198
E-mail: crames@rpi.edu
Website: https://afsws.rpi.edu/AFS/dept/chem-eng/WWW/faculty/cramer/
Education
Ph.D. Chemical Engineering, Yale University, 1986
M.S. Chemical Engineering, Yale University, 1982
B.S. BioMedical Engineering, Brown University, 1978
Biography
Steven Cramer is the William Weightman Walker Professor of Chemical and Biological Engineering at Rensselaer Polytechnic Institute, Troy, New York.  He is currently conducting research on several areas related to protein-surface interactions including: prediction of protein binding affinity and multiscale modeling of chromatographic systems, development of efficient antibody separation systems, fundamental studies in multimodal chromatography, novel chromatographic and diode based electrophoretic lab on chip systems, chemometrics for process analytical technology, multilevel automated peptide synthesis/screening system for design of affinity peptides, smart biopolymer affinity precipitation systems, hierarchical nanobio systems for bioprocessing, biophysics of protein interactions with surfaces, ligands and proteins, platformable strategies for effective removal of process HCPs, and integrated semi-continuous biomanufacturing processes. He stepped down this year from being the Editor-in-Chief of the International journal Separations, Science and Technology after 20 years. Professor Cramer was the awarded the Alan S. Michaels Award for the Recovery of Biological Products (ACS Division of Biochemical Technology) and the ACS National Award in Separation Science and Technology. He was also awarded Rensselaer’s School of Engineering Outstanding Professor Award and the Research Excellence Award. Dr. Cramer was given a Presidential Young Investigator award from the National Science Foundation, the Early Career Award from Rensselaer Polytechnic Institute as well as several teaching awards.  Professor Cramer has been elected a fellow of the American Institute of Chemical Engineers, the American Chemical Society and the American Institute for Medical and Biological Engineering. He has chaired several prestigious meetings including 2 International HIC/RPC Bioseparation Conferences, 2 ACS Recovery of Biological Products Meetings and the Gordon Conference on Reactive Polymers. Prof. Cramer has published over 180 papers in peer-reviewed journals and has 11 patents. Importantly, he has produced 43 Ph.D. students who have gone on to leadership positions in the biotechnology industry and academia.
Research Interests
Bioseparations, Bioprocessing, Chromatography, Proteomics, Microfluidics, Multiscale modeling, Affinity precipitation, Biosensors
Current Research
The research in the Cramer laboratory involves state of the art experimental and theoretical investigations into novel bioseparations systems. Topics include: prediction of protein binding affinity and multiscale modeling of chromatographic systems, design of chemically selective displacers, development of efficient antibody separation systems, fundamental studies in multimodal chromatography, novel proteomics platform using carrier displacement chromatography, novel chromatographic and diode based electrophoretic lab on chip systems, protein unfolding in chromatographic systems, chemometrics for process analytical technology, multilevel automated peptide synthesis/screening system for design of affinity peptides and smart biopolymer affinity precipitation systems. Recent work that combines protein libraries, NMR studies, molecular dynamics simulations and high throughput chromatographic investigations has shed significant insight into the design of a new generation of mixed mode chromatographic systems.